中国血液净化

中国血液净化 ›› 2018, Vol. 17 ›› Issue (03): 197-200.doi: 10.3969/j.issn.1671-4091.2018.03.012

• 综述 • 上一篇    下一篇

质子泵抑制剂相关性肾损伤新认识

钱悦1,倪兆慧1   

  1. 1. 上海交通大学医学院附属仁济医院肾脏科
  • 收稿日期:2017-10-27 修回日期:2018-01-02 出版日期:2018-03-12 发布日期:2018-03-12
  • 基金资助:

    国家自然科学基金面上项目(81570604)；国家自然科学基金面上项目(81370794)；上海市卫计委中西医结合重点项目(ZHYY-ZXYJHZX-1-02)

Novel understanding about proton pump inhibitors related renal injury

  • Received:2017-10-27 Revised:2018-01-02 Online:2018-03-12 Published:2018-03-12

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摘要： 【摘要】质子泵抑制剂(proton pump inhibitors，PPIs)是一类常用的非处方药，目前临床上各科室都应用广泛，很多国家的患者都长期服用此药。近年来，PPIs 相关的安全问题引起了广泛关注，它对各系统的不良反应已被报道，其对肾功能的影响，尤其是引起急性间质性肾炎(acute interstitial nephritis，AIN)已被提出，并成为引起AIN 的常见因素之一。PPIs 相关性AIN 临床表现没有特异性，通常要从平均使用药物6 个月后才能通过活检诊断，AIN 会逐渐发展为慢性肾脏疾病(chronic kidney disease，CKD)并导致终末期肾脏病(end-stage renal disease，ESRD)。至今，PPIs 引起AIN 的人口发病率及其发展为CKD 的机理还不清楚。本文就近年来国际上有关PPIs 引起的肾损伤的最新研究进展进行简述。

关键词: 质子泵抑制剂, 急性间质性肾炎, 急性肾损伤, 慢性肾脏病, 终末期肾病

Abstract: 【Abstract】Proton pump inhibitors (PPIs) are a kind of over the counter (OTC) drugs and are widely used in clinical departments in hospitals. Patients in many countries use these drugs for long period of time. Recently, safety issues related to PPIs have been emphasized. Side effects on various systems have been reported. The effects on renal function, especially causing acute interstitial nephritis (AIN), have been proposed and become one of the common factors for AIN. While AIN always has no specific symptoms, it is hard to make a biopsy diagnosis until 6 months after the use of PPIs. AIN develops gradually as chronic kidney disease (CKD) and finally to end- stage renal disease. Currently, the incidence of AIN caused by PPIs and the mechanism underlying the development of CKD by PPIs remain unclear. This article briefly describes the latest research progress in PPI-related renal disease.

Key words: Proton pump inhibitors, Acute interstitial nephritis, Acute kidney injury, Chronic kidney disease, End-stage renal disease