Abstract: Objective  To explore the clinical effect of hemodialysis using the hemodialyzer with a China-made filter (Weigao HF17) and using the hemodialyzer with an imported filter (FX80, Fresenius, Germany) for the treatment of methanol poisoning.  Methods   A total of 25 patients with methanol poisoning treated with hemodialysis in The Second People's Hospital of Yibin City and The Fifth People's Hospital of Yibin City in March 2022 were selected as the research subjects; 9 patients were treated with HF17 hemodialyzer (HF17 group), and 16 patients with FX80 hemodialyzer (FX80 group). Hospitalization days  and changes of blood methanol concentration, pH, base excess (BE) and lactate before and after the hemodialysis were compared between the two groups.  Results   After the treatment, the changes of blood methanol concentration was higher in HF17 group than in FX80 group (t=-3.849, P=0.001); blood pH (FX80 group: t=-6.005, P＜0.001; HF17 group: t=-3.501, P=0.008) and methanol concentration (FX80 group: t=11.045, P＜0.001; HF17 group: t=13.829, P＜0.001) decreased significantly in both groups; blood pH (t=1.461, P=0.158), BE           (t=0.760, P=0.455), lactate (t=-1.276, P=0.215), and hospitalization days (t=-1.925, P=0.067) had no statistical significances between the two groups.  Conclusion   The hemodialyzer equipped with a China-made filter (HF17) and that equipped with an imported filter (FX80) for the treatment of methanol poisoning have the same effects in the clearance of methanol and its toxic metabolites, maintaining acid-base balance, shortening the hospitalization days, and decrease of expenses.

Key words: Methanol poisoning, Filter, Hemodialysis