Abstract: Vascular calcification (VC) caused by chronic kidney disease-mineral and bone disorder (CKD-MBD) is an important clinical complication, and contributes to the higher cardiovascular mortality in CKD patients. Bone markers can be detected or even involved in the process of VC. Bone markers play important roles in the study of VC. In this paper, we provide an in-depth study of the mechanism of VC, and review the mutual feedback effects among common bone markers such as parathyroid hormone, 25-hydroxyvitamin D, fibroblast growth factor 23 and Klotho (PTH-25OHVitD-FGF23-Klotho). We also summarize the recent research progresses in osteocalcin (OCN), type I collagen carboxy-terminal peptide β special sequence (β-CTX), and total type I collagen amino-terminal extension peptide (tP1NP).

Key words: Vascular calcification, Parathyroid hormone, 25-hydroxyvitamin D; , Osteocalcin, Type I collagen carboxy-terminal peptide β special sequence, Total type I collagen amino-terminal extension peptide