Chinese Journal of Blood Purification ›› 2023, Vol. 22 ›› Issue (11): 821-825,860.doi: 10.3969/j.issn.1671-4091.2023.11.005

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A single-center study of online hemodiafiltration with different frequency to improve quality of life in maintenance hemodialysis patients

SUN Yan-ling, XIE Hua, WANG Jin-ling, XIAO Kun, FENG Qing, LIN Hong-li   

  1. Graduate School, Dalian Medical University, Dalian 116044, China; 2Blood Purification Center, Dalian Renal Care Hospital, Dalian 116023, China; 3Department of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
  • Received:2023-08-09 Revised:2023-08-31 Online:2023-11-22 Published:2023-11-12
  • Contact: 116044 大连, 1大连医科大学研究生院; 116011 大连, 3大连医科大学附属第一医院肾内科 E-mail:linhongli@vip.163.com

Abstract: Objective  To explore the effect of online hemodiafiltration (OL-HDF) once a week and thrice a week on quality of life in patients with maintenance hemodialysis (MHD).  Methods   Patients who received OL-HDF in Dalian Renal Care Hospital from January 1, 2022 to September 30, 2022 were selected and divided into OL-HDF once a week group and OL-HDF thrice a week group; according to the dialysis age in OL-HDF thrice a week group, dialysis age was matched at a ratio of 1:2. The Kidney Disease Quality of Life short Form (SF-36) was applied. The quality of life was assessed by kidney disease component summary (KDCS), physical component summary (PCS) and mental component summary (MCS). Lean tissue index (LTI) was measured by body composition monitor (BCM). Clinical indicators including quality of life scores, LTI, renal function and β2 microglobulin at baseline and after 6 months were compared between the two groups.  Results  A total of 102 MHD patients were included in this study, including 68 patients in OL-HDF once a week group and 34 patients in OL-HDF thrice a week group. Comparison of the indicator changes at baseline and after 6 months in the two groups revealed that KDCS score had no change (t=0.754, P=0.453), the sleep assessment in KDCS was better (t=3.082, P=0.003), the scores of PCS and MCS had no changes (t=  -0.515 and -1/513, P=0.608 and 0.133), and the general health assessment in PCS was better (t=2.442, P=0.016) in OL-HDF thrice a week group, as compared those in OL-HDF once a week group. Changes of the indicators after 6 months showed that hemoglobin (F=6.682, P=0.011), albumin (F=12.294, P=0.001) and LTI (F=7.898, P=0.007) were higher, β2 microglobulin was lower (25.15±3.26mg/L vs. 26.96±5.15mg/L; F=4.710, P=0.032), and spKt/V was higher (1.31±0.21 vs. 1.19±0.15; F=11.975, P=0.001) in OL-HDF thrice a week group, as compared those in OL-HDF once a week group.  Conclusions  OL-HDF treatment thrice a week improves the sleep and nutritional status in MHD patients, probably due to the better dialysis adequacy in these patients.

Key words: Hemodiafiltration, Hemodialysis, Nutritional status, Quality of life

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