Abstract: Objective To investigate the performance of domestic Biolight D800 hemofiltration machine (BLT-D800 Guangdong Biolight Meditech CO., China).  Method  This was a randomized controlled study, using the imported Braun Dialog+ hemofiltration machine (B. Braun Avitum AG, Germany) as the control. A total of 120 patients undergoing maintenance hemodialysis (MHD) at the Blood Purification Center, Guizhou Hospital of Beijing Jishuitan Hospital were recruited for this study. They were divided into 2 groups (n=60/group) by a random number table method. Patients in each group were treated with hemodialysis (HD) 3 times/week and post diluted hemodiafiltration (HDF) once/month. Dialysis complications, treatment effects, dialysate for the machine and other indicators were observed during HDF.  Result  The ratios of hypotension, hypertension, muscle cramp, and choking sensation in chest were similar between the two groups (χ2=0.178, 0.934, 0.167 and 0.164 respectively; P=0.677, 0.358, 0.666 and 0.873 respectively). After HDF treatment, Kt/V, urea reduction rate (URR) and serum β2 microglobulin (β2-MG) were also similar between the two groups (t=     -0.426, 0.165 and 0.046 respectively; P=0.381, 0.692 and 0.833 respectively). Ultrafiltration error was statistically higher in the control group (t=-14.956, P＜0.001).  Conclusion  The domestic BLT-D800 hemofiltration machine is stable for blood purification performance, and is capable to carry out HDF safely and effectively.

Key words: Hemodiafiltration, Hemofiltration machine, Domestic