Abstract: Objective  To explore risk factors of left ventricular diastolic dysfunction (LVDD) in maintenance hemodialysis patients.  Methods  This study was a retrospective study. One hundred maintenance hemodialysis patients in Blood purification Center of Beijing shunyi district hospital were enrolled. According to the results of doppler echocardiography，the early diastolic flow-velocity peak (Ve) and the diastolic flow-velocity peak (Va) were measured at the mitral annulus on the four-chamber apical view of the heart，and the ratio of Ve to Va was calculated. LVDD was defined as Ve/Va＜1. According to the diagnostic criteria, patients were divided into the LVDD group and the normal group. General information and biochemical index was collected and compared between groups，and logistic regression analysis was used to explore the risk factors of LVDD in maintenance hemodialysis patients.  Results   ①In the LVDD group，the rate of diabetic nephropathy patients was higher than that in the control group (χ2=4.332，P=0.024). ②There was significant increases in the levels of systolic blood pressure (t=6.443, P=0.033), calcium-phosphorus product (t=5.419, P=0.043) and C-reactive protein (t=5.107, P=0.036) in the LVDD group，and a significant decrease in the level of serum albumin (t=6.759，P=0.008). ③Logistic regression analysis showed that systolic blood pressure was an independent risk factor of LVDD (OR=1.245，95% CI: 0.987～1.008，P=0.001)，and the albumin serves as a protective factor (OR=2.061，95% CI: 0.091～1.239, P=0.037).  Conclusions  Diabetic nephropathy, systolic blood pressure, malnutrition, calcium-phosphorus product and C-reactive protein are associated with the prevalence of LVDD in maintenance hemodialysis patients. Meanwhile, SBP and serum albumin may be the important independent risk factors of LVDD in maintenance hemodialysis patients.

Key words: Hemodialysis, Left ventricular diastolic function, Risk factors