Abstract: 【Abstract】 Objective To investigate whether the combination of maintenance hemodialysis (MHD) with hemoperfusion (HP) improves left ventricular function in MHD patients. Methods This study was a prospective, randomized, controlled clinical trial. Fifty-nine MHD patients were selected and randomly divided into two groups. Group HD was given hemodialysis (HD) 3 times a week, and group HP+HD received HD 2 times a week and HD combined with HP once a week. This study lasted for 6 months. Left ventricular structure and function of the patients were measured by echocardiography before and after the study. Clinical and laboratory data were also collected. Results Before the study, there were no differences in antihypertensive drugs, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum concentrations of CRP, iPTH and β2-MG, and left ventricular mass index (LVMI) between the two groups. At the end of the six months observation, serum β2-MG and LVMI decreased significantly in group HD+HP (P =0.017 and 0.035, respectively), but showed no differences in group HD. There is a positive correlation between serum β2-MG level and LVMI in group HD+HP (P =0.034). Conclusion MHD combined with HP could reduce LVMI in MHD patients, probably due to the better clearance of middle and large molecular uremic toxins.

Key words: Hemoperfusion, Hemodialysis, Left ventricular hypertrophy