Abstract: Objective To study the effect of the salt and water restriction combined with diuretics therapy on fluid status in patients on continuous ambulatory perito-neal dialysis (CAPD)．Methods 52 patients were randomly divided into two groups: the salt and water restriction group(group A) and salt and water restriction combined with diuretics treatment group (group B). Body weights，mean arterial pressure, urine volume and ultra filtration volume were measured before and 1 month after the treatments in both groups. Results ①In group A, body weights，mean arterial pressure，cardiothoracic ratio of patients were slightly decreased without significance compared to those taken before treatment, while the urine volume and peritoneal ultrafiltration volume were not change; In groupB, body weights，mean arterial pressure, urine volume of the patients were notably decreased compared to those taken before treatment; The urine volume was significantly increased, and the body weights was markedly decreased in group B than in group A after the treatment; ②)Edema of patients in two groups was both alleviated with great degree in group B; ③ There was markedly difference in total efficient rate between two groups with the efficient rate in group A 53.8% and 84.7% in group B. Conclusions The salt and water restriction combined with diuretics therapy may be a safe and effective method to relieve fluid overload in patients on continuous ambulatory peritoneal dialysis.

Key words: Fluid overload, Diuretic