Abstract:

Objective To evaluate the effects of vitamin E-modified dialysis membrane on lipid for patients on haemodialysis. Methods In our study, 40 patients on maintenance haemodi alysis were divided into two groups randomly. Patient s in group A (n=20) received haemodialysis with VitE-modified membrane; patients in group B(n=20) received haemodialysis merely with conventional dialyzers for a period of four weeks. Blood samples were collected prior to the first and thir teenth dialysis sessions to determine the concentrations of malonylaldehyde (MDA ) and vitamin E in plasma and red blood cells (RBC), and of triglyceride (TG), t otal cholesterol (TCH), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein A［Lp(a)］, apolipoprotein B (ApoB) and apolipoprotein A1 (A poA1) in plasma. Results In group A, as compared with the parameters at t he initiation of the study, it was demonstrated that there was significant incre ase in Vit E in both plasma (P=0.003) and RBC (P=0.032), and obvious decline in MDA in both plasma (P=0.043) and RBC ( P=0.033); it was also demonstrated that there was no marke d changes in TC, TG, LDL and HDL, but obvious decline in Lp(a)(P=0.049) and ApoB (P=0.040) and significant increase in ApoA1(P=0.027). In Group B, there was, however, no significant changes d etected at all in all the relevant parameters upon conclusion of the study. Conclusion Our study demon-strates that Vit E-modified membrane may have anti-oxidant effects on haemodialysis patients, and exhibit an advanta ge in improving lipoprotein metabolism, conducive to the prevention of atheroscl erosis. 

Key words: Oxidative stress, VitE-modifi ed dialysis membrane, Lipid