Abstract: Objective To investigate the therapeutic effect of simvastatin on micro-inflammatory state in nondialysed patients with uremia. Methods Sixty-one nondialysed patients with uremia were randomly assigned into simvastatin group (n=31) and patient control group (n=30). Twenty-two healthy volunteers were also observed as the normal control group. Serum C-reactive protein (CRP), Interleukin-6 (IL-6) and nutritional indices were examined in patients before and after treatment for 24 weeks. Results In patients of simvastatin group before simvastatin treatment and patient control group, serum CRP and IL-6 were elevated (P＜0.05) but serum albumin (ALB), proalbumin (PALB) and hemoglobin (HB) were reduced(P＜0.05), as compared with those of normal control group. After simvastatin therapy for 24 weeks, CRP and IL-6 decreased and ALB, PALB and HB increased (P＜0.05), as compared with those before the treatment and those of patient control group. In simvastatin group, serum creatinine and urea nitrogen also declined slightly, but without changes of creatinine clearance rate. Conclusion Simvastatin relieves the microinflammation reactions and improves nutritional status in nondialysed patients with uremia.

Key words: Uremia, Microinflammation