Abstract: Objective This retrospective study evaluated the efficacy of regional citrate anticoagulation (RCA) and low molecular heparin anticoagulation (LMH) methods, and introduced the related nursing experiences. Methods A total of 83 acute kidney injury (AKI) patients treated with continuous renal replacement therapy (CRRT) were studied retrospectively. Variables related to anticoagulation therapy were collected and compared between the patients using RCA and those using LMH. Results The lifetime of hemofilter was longer using RCA method (72±8h) then using LMH method (48±9h) (P<0.05). Hemorrhage accidents were statistically lower in RCA patients (4 cases, 7.55%) than in LMH patients (12 cases, 40.00%; P<0.05). Conclusion Regional citrate anticoagulation is a safer and more effective anticoagulation method for CRRT patients, which can be recommended for clinical use.

Key words: Replacement therapy, Anticoagulation, Sodium citrate