Abstract: 【Abstract】 Objective To observe the effect of hemodialysis (HD), hemodiafiltration (HDF), hemodialysis plus hemoperfusion (HP+HD) and high flux dialysis reuse (HFDR) on clearance of β2-microglobulin (β2M) in uremic patients. Methods We randomly assigned 60 patients treated with hemodialysis for a long period of time in this hospital into HD, HDF, HP+HD or HFDR group, and prospectively observed the changes of β2M in serum and in flow-through dialysate before and after a session. Results Serum β2M increased significantly after treatment in HD group (P＜0.01) and HP+HD group (P＜0.05). However, serum β2M decreased significantly after treatment in HDF and HFDR groups (P<0.01). β2M concentration in flow-through dialysate was higher in HDF and HFDR groups than in HD group (P<0.01). In HDFR group, serum β2M remained lower after the reuse for 10 times, and the serum β2M before dialysis session decreased significantly (P<0.01) after HFDR for 1 year. Conclusion Effective clearance of β2M in serum can be seen in patients treated with HDF and HFDR but not in those treated HD and HP+HD. Long-term application of HFDR can effectively and persistently lower serum β2M (P＜0.01) in maintenance hemodialysis uremic patients.

Key words: Hemodiafiltration, Hemoperfusion, High flux dialysis reuse