Objective To investigate the possible factors affecting the reaction time (RT) in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods A total of 103 CAPD patients from a single center were enrolled in this cross-sectional study. RT in CAPD patients was measured by a standard method, and their clinical data were also collected. Data comparison between groups was performed using one-way ANOVA. Simple correlation analysis and multiple linear regression analysis were used to explore the relationship between RT and other factors in CAPD patients. Results RT was longer in CAPD patients than in healthy people. Multiple linear regression analysis showed that age (P =0.049), education level (P =0.008), handgrip strength (P =0.011) and history of cardiovascular and/or cerebrovascular diseases (P =0.049) were the independent factors relating to RT values in CAPD patients (R2adj =0.326, P＜0.05). Conclusions RT is longer in CAPD patients than in healthy people. Age, education level, nutrition status, history of cardiovascular and/or cerebrovascular diseases are the factors influencing RT value in CAPD patients. Therefore, lagged RT may have impact on rehabilitation in these patients.