Abstract: 【Abstract】 Objective To study the adsorption of paraquat by different hemoperfusion adsorbents. Methods We added 0.5% paraquat solution 200 ml, 100ml, 50ml and 0.01% paraquat solution 200 ml in the extracorporeal circulation system for adsorption for 2 hours, observed the change of paraquat concentration, and calculated the adsorption rate of paraquat by activated carbon and macroporous resin. Results when paraquat concentration was 0.5% and the circulation volume was 200ml, the adsorption rate of parquet by activated carbon and resin was 46% and 35%, respectively. With the decrease of circulation volume, the adsorption rate was increased. When the paraquat concentration was 0.01% and the circulation volume was 200ml，the adsorption rate by activated carbon and macroporous resin was 95% and 87%, respectively. Conclusion At any paraquat concentrations, the adsorption rate of activated carbon is higher than that of macroporous resin but without statistical significance. Clinically, either charcoal kidney or resin adsorption column can be used for the clearance of paraquat by hemoperfusion therapy.

Key words: Hemoperfusion adsorbent, Activated carbon, Macroporous resin, Adsorption rate