Abstract: 【Abstract】 Objective To retrospectively analyze the clearance of toxins in hepatic failure caused by severe hepatitis by hemoperfusion using HA macroporous high molecular absorbent. Methods Forty patients with hepatic failure caused by severe hepatitis were treated with hemoperfusion using HA macroporous resin HA330-Ⅱ. Their hepatic and renal functions were monitored, and several serum inflammatory markers were measured before and after the treatment. Results After the hemoperfusion, clinical symptoms and signs improved to various extents. ALT, total and direct bilirubin lowered remarkably (P<0.01), PTA increased obviously (P<0.01), and serum IL-6, and TNF-α decreased significantly. However, serum electrolytes remained unchanged. Conclusions The toxins in hepatic failure caused by severe hepatitis can be efficiently cleared by the hemoperfusion using HA resin as the adsorbent. After the hemodialysis, patients’ clinical symptoms and signs improved to various extents.

Key words: Hemoperfusion, Hepatic failure