【Abstract】 Objective To investigate the incidence and risk factors of contrast-induced nephropathy (CIN) in patients underwent coronary angiography (CAG). Methods From April 2009 to July 2009, patients admitted to the six centers in Pudong area in Shanghai for CAG were prospectively collected. Overall incidence of CIN and the incidences under different conditions were analyzed. Patients were divided into CIN group and non-CIN group based on the presence of CIN, and the two groups were compared. Risk factors for CIN were analyzed. Results Of the 197 patients, 17 experienced CIN, and the overall incidence was 8.63%. The CIN incidences of the aged, female, patients with type 2 diabetes, myocardial infarction, heart function>II, and contrast media volume>180ml were 18.1% (13/72), 14.9% (10/67), 14.1% (10/71), 17.4% (4/23), 21.7% (5/22), 22.2%(8/36) ( p<0.05), respectively, much higher than those of non-aged, male, patients without type 2 diabetes, myocardial infarction and heart function I～II, and contrast media volume<180ml. There were significant differences in age, hemoglobin, hematocrit, cholesterol, two-hour postprandial plasma glucose, and creatinine clearance before CAG (P<0.05) between CIN and non-CIN patients. Multivariate analysis indicated that age>70 (relative ratio [RR]=7.02, P=0.003), myocardial infarction (RR=4.67, P=0.042), and contrast volume>180ml (RR=4.17, P=0.022) were the risk factors for CIN. Conclusion We should pay attention to the presence of CIN in hospitalized patients undergoing CAG. The incidence of CIN was higher in aged patients, and patients with type 2 diabetes, hypertension, anemia, or hyperlipidemia. Therefore, measures should be performed to prevent CIN, especially in the patients undergoing CAG.