Abstract: 【Abstract】Objective To study the effectiveness and the optimal disease course in the application of non-biologic artificial liver support system in patients with acute severe toxic hepatopathy. Methods A total of 61 patients diagnosed with acute severe toxic hepatopathy were enrolled in this study. Twenty-eight of them were treated with the non-biologic artificial liver support system in addition to routine medicinal therapy as the treatment group, and 33 patients were treated with routine medicinal therapy as the control group. Results In the treatment group, the improvement of clinical manifestations and laboratory indices including transaminases, total bilirubin, blood ammonia, cholinesterase and coagulation time was obviously better than that in the control group (P<0.01). Mortality rate and hospitalization day decreased (P< 0.01), and no severe complications occurred in the treatment group. Conclusion Non-biologic artificial liver support system is effective for acute severe toxic hepatopathy. Artificial liver support should be considered when the patients exhibit the increase of transaminases and total bilirubin more than two folds, significant prolongation of coagulation time, and hepatic encephalopathy after routine medicinal therapy.

Key words: Liver injury, Non-biologic artificial liver