Abstract: 【Abstract】 Objective To observe the impact of amlodipine besylate combination with benazepril on blood pressure and blood pressure variability in peritoneal dialysis patients. Methods A total of 145 peritoneal dialysis patients with hypertension were divided into two groups: treatment group (n=80) and control group (n=65). The treatment group was treated with amlodipine besylate and benazepril, and the control group with nifedipine sustained release tablet and benazepril. Follow-up of the patients lasted 24 months beginning from the treatment for one month. Comparisons were made for changes of blood pressure, blood pressure variability, and cardiovascular events including cardiac failure, acute coronary syndrome and sudden death between the two groups.  Results In the two groups, blood pressure and blood pressure variability were significantly decreased after the treatment (P＜0.01). Blood pressure variability was significantly lower in the treatment group than in the control group (P＜0.01), but the change of blood pressure was statistically insignificant between the two groups (P>0.05). The prevalence of cardiovascular events and cardiovascular mortality rate were significantly lower in the treatment group than in the control group (P＜0.01). Conclusion Amlodipine besylate combined with benazepril or nifedipine sustained release tablet combined with benazepril can efficiently control blood pressure in peritoneal dialysis patients. However, amlodipine besylate combination with benazepril was more effective in lowering blood pressure variability and thus the prevalence of cardiovascular events and cardiovascular mortality rate.

Key words: Peritoneal dialysis, Amlodipine besylate, Benazepril, Blood pressure variability