Abstract: 【Abstract】Objective To compare the long-term therapeutic efficacy in patients with daytime ambulatory peritoneal dialysis (DAPD) and those with traditional continuous ambulatory peritoneal dialysis (CAPD), and to explore the long-term peritoneal dialysis method suitable for Chinese patients.  Method A total of 32 outpatients or inpatients subjected to peritoneal dialysis in our hospital were selected and randomized into group A (n=16) and group B (n=16). Patients in group A were treated with CAPD by using the dialysate 8L/day, four exchanges per day, and dialysate left in abdomen cavity at night. Patients in group B were treated with DAPD by using 8L dialysate at daytime, dialysate exchange every 3-4 hours, and evacuation of dialysate from abdomen at night. Long-term monitoring for the patients was carried out. Thoroughness of dialysis was compared between the two groups, including urea clearance index (Kt/V), creatinine clearance rate (Ccr), nutritional status parameters of subjective global assessment (SGA) and serum albumin (sALB), hemoglobin (Hb), carbon dioxide combining power (CO₂CP), serum potassium (K+), serum calcium (Ca²+), serum phosphorus (P-), intact parathyroid hormone (iPTH), mean arterial blood pressure, prevalence of peritoneal infection, number of cases on maintenance dialysis, valid duration (months) of maintenance dialysis, and employment rate. Barthel index (BI) was used for the evaluation of daily life ability, and Hamilton depression rating scale (HAMD) for the evaluation of depression degree. Urinary and ultrafiltration volume were recorded everyday. Data were presented as mean±SD, variance analysis was used for the comparison of mean values, and t-test or χ² test for the comparison between two groups. P＜0.05 was considered to be statistically significant.  Results Residual urinary volume, ultrafiltration volume, Kt/V (weeks), Ccr, CO₂CP, K+, and Ca²+ were statistically insignificant between the two groups (P＞0.05). However, nutritional status, Hb, P-, iPTH, mean arterial blood pressure, prevalence of peritoneal infection, number of cases on maintenance dialysis, valid duration (months) of maintenance dialysis, employment rate, BI, and HAMD were better in group B than in group A (P＜0.05). Conclusion Patients under DAPD had better clinical efficacies than those under CAPD in maintenance dialysis duration, thoroughness of dialysis, nutritional status, blood pressure, prevalence of peritoneal infection, daily life ability, and depression degree, although the dialysate volume used was similar in the two groups.

Key words: Chinese patients, Peritoneal dialysis, Thoroughness of dialysis, Life quality