Abstract: 【Abstract】Objective Volume control is critical for peritoneal dialysis. Although peritoneal equilibration test (PET) has been used to clarify the peritoneal membrane characteristics, it is unable to adequately predict peritoneal fluid removal and appropriately optimize the dwelling time. In the present study, we applied computer simulation and performed a more detailed evaluation of the fluid kinetics in patients with different ultrafiltration (UF) capacity.  Methods Patients who used three to four exchanges of 2.5% glucose dialysate per day (poor UF capacity group) and patients who used three to four exchanges of 1.5% glucose dialysate per day (good UF capacity group) to achieve adequate amount of peritoneal fluid removal were included in the present analysis. All included patients were asked to record appropriately their dialysis exchanges for assessment of their peritoneal fluid transport characteristics.  Results Seventeen continuous ambulatory peritoneal dialysis patients were selected in the present study, nine in poor UF capacity group and eight in good UF capacity group. Patients in poor UF capacity group had significantly higher daily glucose exposure (p＜0.01), higher dialysate-to-plasma ratio of creatinine (D/P creatinine) (p＜0.05) values, and higher peritoneal fluid absorption rate (Ke) (P＜0.01), as compared to patients with good UF capacity. Conclusions Our results suggest that patients with poor UF capacity have significantly higher peritoneal small solute transport rate, and more importantly, higher peritoneal fluid absorption rate as compared to patients with good UF capacity.

Key words: Peritoneal dialysis, Fluid kinetics, Ultrafiltration capacity