Abstract: 【Abstract】Objective To investigate the incidence of depression and anxiety and their related factors in continuous ambulatory peritoneal dialysis (CAPD) patients, and to evaluate the correlation of depression and anxiety with Engle coefficient, treatment comp1iance, complication, and nutrition status in these patients. Methods Seventy-five outpatients with end-stage renal disease and treated with CAPD were recruited in this cross-sectional study. Their demographic data and primary disease were collected. Patient’s family income was assessed by Engle coefficient. Anxiety and depression were rated by the Hamilton depression rating scale (HAMD) and Hamilton anxiety rating scale (HAMA). Residual renal function was evaluated by creatinine clearance calculated by the MDRD equation. Nutrition status was measured by the subjective global assessment (SGA) in combination with blood biochemical indices. We also estimated their complications by Charlson coefficient, and their activities by EOCG/Karnofsky activity indices. Results In the 75 outpatients recruited from this dialysis center, 28 cases (37.33%) were identified as having depression and/or anxiety symptoms. The occurrence of depression and anxiety symptoms related to the disease status and income level (P＜0.05). CAPD patients with depression or anxiety had less activities, poor compliance, more complications, and higher malnutrition rate. Psychological symptoms correlated negatively with hemoglobin, serum albumin, urea nitrogen and Kt/V (P＜0.01), and positively with nutritional status (P＜0.01). On the other hand, psychological problems significantly affected nutritional status (OR= 3.610, P＜0.05).  Conclusions Inuremic patients on CAPD, depressive and anxious symptoms were frequently encountered. Most CAPD patients with psychological symptoms were associated with malnutrition, poor compliance or other complications. Moreover, psychological symptoms induced the presence of malnutrition. Psychological symptoms related not only to the primary disease and its complications, but also to patient’s income level.  Appropriate treatment of depression and anxiety may be helpful for the effectiveness of peritoneal dialysis in these patients.

Key words: Uremia, Peritoneal dialysis, Psychiatric symptoms, Nutritional status