Abstract: 【Abstract】 Objective To study the effect of losartan on left ventricular hypertrophy (LVH) in maintenance hemodialysis (MHD) patients, and the correlation between the effect of losartan and the status of inflammation and oxidative stress. Methods MHD patients with LVH in our dialysis center were assigned into losartan group or placebo group. Patients took losartan 50～100 mg/d or placebo for 6 months．Left ventricular mass index (LVMI) was measured by echocardiography. Hs-CRP and MDA level were detected at the baseline, and after the treatment for 3 months and 6 months.  Results Compared the parameters at baseline condition, all parameters we tested decreased significantly after losartan treatment for 6 months, LVMI from 140.16±22.13 g/m2 to 125.21±19.39 g/m2 (F=5.13, P＜0.01), hs-CRP from 6.22±2.03 mg/L to 3.79±1.73 mg/L (F=6.14, P＜0.01), and MDA from 5.45±1.87 mol/L to 4.36±1.62 mol/L (F=5.47, P＜0.01). There was a correlation between the decrease magnitude of LVMI and the decrease magnitude of CRP or MAD (r= 0.805, t=2.91, P＜0.01 and r=0.778, t=2.72, P＜0.01, respectively). In placebo group, these parameters changed insignificantly. Conclusion Losartan is effective to reverse LVH. There is a the correlation between the effect of losartan and the status of inflammation and oxidative stress.

Key words: Losartan, Maintenance hemodialysis, Left ventricular hypertrophy, Echocardiography