Abstract: 【Abstract】Objective To investigate the clearance effect of three blood purification methods on serum β2-microglobulin (β2-MG) and parathyroid hormone (PTH) levels in maintenance hemodialysis patients.  Methods A total of 54 patients on maintenance hemodialysis treated in our hospital during the period of May 2008 to September 2010 were recruited. They were randomly assigned into 3 groups, hemodialysis (HD) group (n=18), hemodiafihration (HDF) group (n=18), and hemoperfusion + hemodialysis (HD+HP) group (n=18). Blood samples were taken for the assays of serum β2-MG and PTH before and after the treatment.  Results Serum β2-MG and PTH levels decreased after the treatment in all 3 groups. Serum β2-MG and PTH levels decreased significantly in HP+HD group and HDF group after the treatment (t=12.47, P=0.0034 in HP+HD group; t=8.57, P=0.0082 in HDF group), but insignificantly in HD group (P＞0.05). The clearance effects of β2-MG and PTH were better in HP+HD and HDF groups than in HD group (t=10.19, P=0.0049 for β2-MG clearance; t=9.43, P=0.0071 for PTH clearance), but without significant differences between HP+HD group and HDF group (t=1.41, p=0.33). Conclusion Serum β2-MG and PTH can be cleared efficiently by HD+HP or HDF, but inefficiently by HD.

Key words: Hemodialysis, Hemoperfusion, Hemodiafiltration, β2-microglobulin, Parathyroid hormone