Abstract: [Abstract] Objective To study the clinical application of continuous blood purification (hemoperfusion and hemofiltration) in patients with severe drug eruption. Methods 66 patients with severe drug eruption were randomly divided into two groups, general treatment group （n=33） and blood purification group（n=33）. General treatment group was treated by normal treatment, while the blood purification group treated by early continuous blood purification treatment on the basis of normal treatment. Acute physiology and chronic health evaluationⅡ（APACHE II ）score of the two groups recorded on the first day before treatment and post-treatment 8th,15th day, and blood samples collected on the first day and the 8th,15th day after treatment for plasma contents of TNF-a,IL一6 ,and the plasma levels of hs-CRP were compared and analyzed. Observe and compare the improvement of the whole body skin rash condition between the two groups on the 8th day after treatment, and compare the complications and prognosis on the 28th day after treatment. Results After 8days of treatment, drug eruption were improved remarkably, the total efficiency rate of blood purification group was 87.87％,while the general treatment group was 54.54％, the difference was statistically(χ2=31.29,P<0．01). and APAPHEⅡ score after 8days and 15days were all decreased gradually, while the differences between two groups have obvious statistical significance (P<0.05); 8days after treatment ,blood purification group for plasma contents of TNF-a,IL一6 , and the plasma levels of hs-CRP determined were decreased significantly than that general treatment group（P<0．01）;the prognosis within 28 day, the occurrence of septic （χ2=12.16，P<0．01）and MODS（χ2= 7.58，P<0．01) ,and the morbidity of detection decreased obviously (χ2= 6.42，P﹤0．05) in the blood purification group compared with the general treatment group. Conclusion Patients with Severe Drug Eruption received treatment of continuous blood purification have better clinical effective, treatment of continuous blood purification can improve the prognosis of the patients .It is worthy of promotion.

Key words: Severe Drug Eruption, continuous blood purification, Sepsis, multiple organ dysfunction syndrome, Prognosis