Abstract: 【Abstract】 Objective To study the clearance effect of plasma perfusion for the plasma paraquat (PPQ) using dual- cartridge in series and to explore the feasibility of dual-tank in series plasma perfusion in the treatment of paraquat poisoning. Methods 16PQ-poisoned Patients who arrived our poisoning Center within 24 hours after paraquat poisoning were prospectively enrolled. Bual-tank in series plasma perfusion (blood flow rate of 180 ml / min, Plasma flow 40ml / min) was performed and Activated carbon cartridge were changed every 3 hours.The concentration of PPQ was recorded in the before, during and after of the two cartridge every 3h. Results 1) The change of paraquat concentration: During the first plasma perfusion, the concentration of PPQ before, during and after the two cartridge (16 cases)were: 6.70 (6.44,4.36), 5.75 (3.65,7.53) and 4.40 (2.55,6.33); before and after the single cartridge（18 cases）were：7.25(5.28,9.15)and 5.55 (3.55,7.25). 2nd the two cartridge (16 cases) were: 4.00 (1.55,4.25), 2.70 (0.90,3.50) and 1.90 (0.35,2.85); the single cartridge（18 cases）were : 4.50(2.28,6.15)and 2.80(0.83,4.98).3rd the two cartridge (8 cases) were: 2.00 (1.03,2.70), 1.50 (0.68,2.15) and 0.95 (0.45,1.70); the single cartridge（15cases）were : 3.10(0.97,4.60)and 2.30(0.40,3.35).4th the two cartridge (6 cases) were: 1.14 ± 0.96,0.87 ± 0.78 and 0.65 ± 0.67; the single cartridge（11cases）were :1.90(0.79,3.05)and 0.90(0.45,2.40). 2) Paraquat clearance rate of each cartridge: During the first plasma perfusion, the Paraquat clearance rate of double cartridge, cartridge1and cartridge2 were: 14.36 ± 5.72,8.01 ± 4.04 and 8.49 ± 3.77; the Paraquat clearance rate of single cartridge（18cases）was : 10.37±5.67.when the second plasma perfusion, the Paraquat clearance rate of double cartridge, cartridge1and cartridge2 were : 21.53± 7.74,12.91 ± 7.76 and 16.12 ± 7.23; the single cartridgewas : 15.58±8.14. 3rd, the double cartridge, cartridge1and cartridge2 were: 18.39 (14.29,25.84), 9.26 (8.96,12.21) and 10.25 (7.38,19.00); the single cartridge was : 15.54±8.39.4th(6 cases): 19.17 (13.33,25.61), 9.35(4.42,13.14) and 13.45 (8.22,11.28); the single cartridge was:11.43(6.86,14.74). Conclusion Compared with the single cartridge plasma perfusion, dual-cartridge plasma perfusion can increase the clearance rate of plasma paraquat significantly and may be a method for the treatment of paraquat poisoning.