Abstract: [Abstract] Objective: Using historical prospective cohort study method, to evaluate the quality of life(QOL) of peritoneal dialysis (PD) patients, and compare the difference of in QOL between diabetes and non-diabetes patients, as well as analysis the factors impacting on QOL of diabetes peritoneal dialysis patients. Methods: 238 patients on maintenance peritoneal dialysis in our center were included from January 2005 to March 2012. General information、chemical test、complication、residual renal function and peritonitis of 118 diabetes and 120 non-diabetes patients were evaluated . QOL and endpoints events were also followed-up. Results: (1) In contracting with non-diabetes patients, the diabetes patients had shorter dialysis age（30.34±27.03 vs 38.52±22.14，Ｐ＜0.01）、higher eGFR （11.26±3.67 vs 8.88±4.01，Ｐ＜0.01）and lower serum albumin level（28.09±4.61 vs 32.41±5.17，Ｐ＜0.05）; (2) During one to three years of dialysis, SF-36 and the most QOL scales were much lower in diabetes patients than in non-diabetes patients. And the difference was more significant in two to three years after dialysis; (3) Qol of non-diabetes patients was improved in the first dialysis year and declinded in the following two years, while that of diabetes patients consisted declining in three years; (4) Different PD operators had influence on QOL of patients. In two groups, QOL of patients who operated by themselves were highest while by family members were lower and by housemaids were lowest（Ｐ＜0.01）; (5) Charlson complication index（r=-0.752，P =0.000）、peritonitis （r=-0.481，P =0.002）and the quantity of urine protein（r=-0.532， P =0.000） were all negtively related with QOL. Conclusion: (1) QOL of diabetes patients were much lower than that of non-diabetes patients;(2)There were differences of QOL changing trend between diabetes patients and non- diabetes patients;(3) QOL of diabetes patients were influenced by many factors such as operators、complications、peritonitis and urine protein.

Key words: Peritoneal Dialysis, diabetes nephropathy, quality of life