Abstract: [Abstract] Objective To investigate the relationship between carotid intima-media thickness and25-hydroxy vitamin D3 in maintenance hemodisysis uremic patients. Methods carotid intima-media thickness was examined by ultrasonograph. According to the carotid intima-media thickness value the maintenance hemodisysis uremic patients were divided into two sub-groups: IMT more than and equal 1.0mm, IMT less than 1.0mm. serum amyloid A and tumor necrosis factor-α were determined by ELISA. 25-hydroxy vitamin D3 were determined by Radioimmunoassay. Clinical data were collected. Results Among 63 the maintenance hemodisysis uremic patients, IMT more than and equal 1.0mm was revealed in 19 cases, IMT less than 1.0mm in 44 cases. 25-hydroxyvitamin D3 was negatively correlated with IMT. Serum amyloid A , tumor necrosis factor-α, age, hemodialysis time, systomic pressure, pulse pressure and low density lipoprotein cholesterol increased significantly in patients of IMT more than and equal 1.0mm,as compared with patients of IMT less than 1.0mm. Pearson correlation analysis showed IMT had the strongest correlation with 25-hydroxyvitamin D3 , serum amyloid A and tumor necrosis factor-α. Conclusion 30.2% patients, IMT was more than and equal 1.0mm. IMT had the strongest correlation with 25-hydroxyvitamin D3 , which may associate with advanced cardiovascular diseases in the maintenance hemodisysis patients.

Key words: [Key Words] uremic, hemodisysis, 25-hydroxyvitamin D3,, arotid intima-media thickness