Abstract: To determine the serum level of fibroblast growth factor 23(FGF23) in maintenance hemodialysis(MHD) patients and explore the relationship between FGF23 and ventricular hypertrophy. Methods: Forty MHD patients and twenty people(control group ) whose renal functions were normal were enrolled in this study. Phosphate、calcium、alkaline phosphatase in their serum were determined . The level of FGF23 and 1,25-(OH)2D3 in serum were detected by the method of ELISA.The patients in MHD were divided into LVH group and non-LVH group according as LVMI. Results: (1)The Log FGF23 and LogPTH in MHD group was much higher than control, Log1,25-(OH)2D3 in MHD group was lower than control.(2)The Log FGF23 and Log PTH in LVH group was much higher than non-LVH group .(3)LVMI was positively correlated with Log FGF23 and Log ALP.(4)Multiple linear regression analysis revealed that the level of Log FGF23 and LogALP was the influencing factor of LVH in MHD patients.Conclusion: The serum level of FGF23 in MHD patients is extremely higher, and the elevation of FGF23 is relative to the left ventricular hypertrophy.

Key words: fibroblast growth factor 23, left ventricular hypertrophy, parathyroid hormone