Abstract: 【Abstract】Objective To investigate the alteration of T-lymphocyte subsets in hemodialysis patients with chronic hepatitis B (CHB-HD) and its influencing factor. Methods Two groups of patients were included for investigation: 43 HD patients with CHB (CHB-HD group) as study group, and 46 HD patients with non-CHB (HD group) as control group. T-lymphocyte subsets were measured by flow cytometry. Biochemical parameters, hs-CRP and iPTH were also measured. The differences between two groups were analyzed and influencing factors of T-lymphocyte subsets in CHB-HD patients were determined. Results Compared with ordinary HD patients, the alteration of T-lymphocyte subsets in CHB-HD patients were mark: CD3+T-lymphocytes were greatly reduced（883.12±331.74 / mm3 vs 1060.94±337.01 / mm3, P＜0.05）;CD8+ T-lymphocytes were also dramatically decreased（336.65±153.95 / mm3 vs 441.89±209.76 / mm3, P＜0.05. Pearson correlation analysis showed that the count of CD3+,CD8+ T-lymphocyte and the level of PALB were positively correlated. Conclusion The disorders of T-lymphocyte subsets in hemodialysis patients with chronic hepatitis B were further aggravated than ordinary hemodialysis patients, and the levels of ALB and PALB maybe positively correlated with these change

Key words: chronic hepatitis B, hemodialysis, T-lymphocyte subset