Abstract: [Abstract]:OBJECTIVE To determine whether 1% Cefazolin-30% sodium citrate prevents the catheter-related bacteremia and influences the incidence of the dysfunction of catheter.METHODS A randomized prospective controlled study was undertaken.25 hemodialysis patients were randomly divided into two groups,13 of group patients receive 1% Cefazolin-30% sodium citrate into each lumen of the catheter three times a week,12 of control group patients receive heparin locks only three times a week for 6 months.The incidence rates of the catheter-related bacteremia,the catheter dysfunction,and other adverse reactions were recorded. RESULTS The incidence of catheter-related bacteremia was 0.85/1000 catheter days in the group and 2.29/1000 catheter days in the control group, The incidence of catheter dysfunction was 1.17% in the group and 2.87% in the control group, The incidence of catheter-related bacteremia and catheter dysfunction between the two groups was statistically significant(p＜0.01）.The serum Ca2+、Mg2+、ALT、AST between the two groups showed no obvious changes before and after treatment(p＞0.05）.The main side effect in the group was 4.2‰,the symptom was spontaneous remission.CONCLUSION As compare with the heparin catheter locks, 1% Cefazolin-30% sodium citrate can effectively reduce the catheter-related bacteremia and catheter dysfunction,and it was safer.

Key words: [key words] Cefazolin, sodium citrate, hemodialysis, long-term indwelling catheter