Abstract: Objective To observe the changes of calcium-phosphorous metabolism in patients with peritoneal dialysis or hemodialysis. Methods Serum calcium, phosphorus and parathyroid hormone (PTH) were measured in 45 peritoneal dialysis and 97 hemodialysis patients after the treatments for 0, 3, and 6 months. Their residual urine output was recorded. Patients with higher PTH were treated with calcitriol, and were treated with low calcium (1.25 μmol/l) dialysate for hemodialysis patients. Results At the beginning of the treatments, the prevalence rate of hyperphosphatemia, higher PTH, and lower PTH was 51.5%, 37.1% and 8.2%, respectively, in hemodialysis group, and was 22.2%, 17.8% and 24.4%, respectively, in peritoneal dialysis group, and the residual urine output >500 ml/day was found in 6.2% patients in hemodialysis group, and in 55.6% patients in peritoneal dialysis group, significantly different between the two groups. In hemodialysis and peritoneal dialysis groups, serum PTH decreased after the treatment with calcitriol and low calcium dialysate for 3 and 6 months (F=23.803 and 4.9896, respectively, P＜0.05). In hemodialysis group, serum calcium was lower than that before the treatment (F=19.879, P＜0.05). Conclusion For uremic patients, peritoneal dialysis was better than hemodialysis in maintenance of normal calcium phosphorus metabolism and protection of residual renal function. Appropriate diet, low calcium dialysate, and calcitriol therapy should be considered for improvement of calcium-phosphorus metabolism in dialysis patients.

Key words: Hemodialysis, Peritoneal dialysis, Calcium, Phosphorus