Abstract: 【Abstract】 Objective To investigate the effectiveness and safety of plasma diafiltration (PDF) in the treatment of septic acute kidney injury. Method Twelve patients with septic acute kidney injury were enrolled in this study. They were divided based on randomized blocks into PDF group or continuous veno-venous hemofiltration (CVVH) group. Baseline characteristics, organ functions, overall conditions, survival, kidney survival as well as sufficiency and safety of PDF were statistically analyzed. Result Six patients were included in each group, and there were no significant differences in baseline characteristics between the two groups. After treatment, APACHE Ⅱ score (P=0.032) and corrected mortality risk (P=0.015) reduced significantly and the kidney survival improved significantly (P=0.0203) in PDF group, as compared with those in CVVH group. PDF was better than CVVH in improving circulation, kidney and lung functions but without statistical significances (P＞0.05) between the two groups. Survival rate, blood purification sufficiency, and safety were similar between the two blood purification methods. Conclusion PDF had the advantages of improving organ functions in patients with septic acute kidney injury.

Key words: Plasma diafiltration, Sepsis, Molecular weight cut-off