Chinese Journal of Blood Purification ›› 2014, Vol. 13 ›› Issue (05): 372-376.

Previous Articles     Next Articles

The meta analysis of influence of online hemodiafiltration on survival rate of maintenance hemodialysis patients

  

  • Received:2013-12-02 Revised:2014-02-28 Online:2014-05-12 Published:2014-05-11

Abstract: Objective To evaluate the effect of online hemodiafiltration(OL-HDF)in the survival rate of maintenance hemodilysis(MHD) patients.Methods Randomized controlled trials(RCT),prospective controlled trials(PCT) and prospective cohort trials studying the effect of OL-HDF on survival rate of MHD patients were searched in the Pubmed /Medline, EMBASE、and Cochrane Library electronic databases, then the odds ratio was calculated. Results 5009 patients were included in this study: the effect of survival rate was compared in the OL-HDF and HD group. Compared with the HD group, the survival rate of OL-HDF group wasn not improved (Fixed effect model, OR=0.53,Z=5.51,P<0.00001,I2=38%). The subgroup of OL-HDF patients treated with a high substitution volume per session had better overall mortality compared with the HD group. There were no significant difference of overall mortality rate between low volume OL-HDF group and HD group(OR=1.0,Z=0.01,P=0.99,I2=0%). Conclusions High volume OL-HDF may not improve the survival rate of MHD patients, associated with OL-HDF substitution volume.