Abstract: 【Abstract】 Objective To observe the long-term effect of 1.25 mmol/l calcium in dialysate (LCaD) on mineral metabolism in maintenance hemodialysis (MHD) patients. Methods A total of 50 chronic renal failure patients with MHD for more than 3 months were randomly recruited from our hospital. The effects of LCaD on serum calcium, phosphorus, and intact parathyroid hormone (iPTH) were observed after the treatment for 3, 6, 9 months. Results After the use of LCaD, we found that serum calcium level dramatically declined in the patients with different serum calcium levels and different serum iPTH levels (P＜0.05). Serum phosphorus was unchanged after the treatment of LCaD for 3 and 6 months, but decreased after the treatment for 9 months (P＜0.05). Serum iPTH was unchanged after the treatment for 3 months, and increased significantly after the treatment for 6 and 9 months (P＜0.05). Conclusion Low calcium in dialysate can decrease the serum calcium level in some of MHD patients, and can effectively control the serum phosphorus. However, low calcium in dialysate will increase the risk of secondary hyperparathyroidism. Therefore, calcium and active vitamin D preparations should be supplemented at the same time.

Key words: hemodialysis, 1.25mmol/L calcium concentration in dialysate, mineral metabolism