Abstract: Objective To analyze the prognosis of peritoneal dialysis (PD) patients and to investigate the association between blood pressure (BP), the variability of BP and mortality. Methods We included 482 PD patients who had regular visits in our PD center from 1999 to Jan. 1, 2015 for survival analysis and to identify the risk factors for mortality. Sixty-nine of the PD patients who had been on PD for more than 3 months before Jan. 31, 2008 were involved in the analysis of the relationship between BP variability and mortality. Consecutive 6 office BP measurements once a month during 2008 were collected from every patient, and the
coefficient of variation (CV) for BP was used as an indicator of BP variability. Baseline clinical data and laboratory tests were also reviewed. Patients were followed up for 72 months. All-cause mortality and cardiovascular mortality were analyzed by Cox regression. Results Two hundred and twenty-four PD patients died in the follow-up period for 16 years. Diabetes (HR 2.245, 95% CI 1.718～2.932, P＜0.001) and advanced age (HR 2.840, 95% CI 2.065～3.906, P＜0.001)were the risk factors for mortality. Cardiovascular event (52.2%) and infection (25%) were the two major causes of death. The CV for systolic blood pressure was 9.8±4.7%. Among the 69 PD patients, 33 patients died. Systolic BP ≥153mmHg was an independent predictor for allcause mortality (HR 2.848, 95% CI 1.156～7.015, P=0.023) and cardiovascular mortality (HR 3.122, 95% CI 1.012～.635, P=0.048). BP variability was not a predictor for mortality in PD patients. Conclusion Hypertension was an independent predictor for all-cause and cardiovascular mortality for PD patients, but BP variability could not be proved to be a factor affecting the prognosis of PD patients.

Key words: Peritoneal dialysis, Blood pressure, Blood pressure variability, Prognosis