Abstract: 【Abstract】Objective This retrospective study aimed to discuss the effect of plasmapheresis (PE) in the clearance of serum inflammatory mediators and recovery of liver function in chronic severe hepatitis B (CSHB). Methods CSHB patients treated in our hospital in the period between 2013 and 2014 were retrospectively analyzed. Comprehensive therapy combined with PE was used to treat these patients. Every PE used 3L fresh frozen plasma of same blood type. Serum inflammatory mediators and liver function were compared before and after the treatment. Results A total of 45 patients (mean age 42.3 years old) were retrospectively analyzed. After the treatment, serum inflammatory mediators decreased significantly as compared with those before the treatment: CRP (20.4 ± 14.3 mg/L vs. 28.5 ± 11.3 mg/L; t=3.613, P＜0.001), TNF- α (181.0±39.0 vs. 275.4±50.9; t=8.765, P＜0.001), IL-6 (252.9±34.8 pg/mL vs. 351.9±41.5 pg/mL; t=12.262, P＜0.001), and IL-8 (458.4±86.4 pg/mL vs. 665.9±84.6 pg/mL; t=11.513, P＜0.001). After the treatment, serum total cholesterol (2.5 ± 0.8 mmol/L vs. 2.1 ± 0.3 mmol/L; t=3.141, P＜0.001), cholineasterase activity (3448.4±566.3 U/mL vs. 2635.9±984.6 U/mL; t=5.442, P＜0.001), and albumin (31.2± 2.7g/L vs. 28.6±3.5 g/ L; t=8.753, P＜0.001) increased, and PT (26.6±4.3 vs. 34.6±6.7; t=6.741, P＜0.001), ALT (55.9±5.0 IU/L vs. 82.0±5.7 IU/L; t= 16.531,P＜0.001), AST (53.4±2.4 IU/L vs. 80.0±3.1 IU/L; t=15.563, P＜0.001), and TBIL (13.4±1.3 mmol/L vs. 15.7±0.82 mmol/L; t=10.326, P＜0.001) decreased as compared with those before the treatment. Conclusion The PE treatment can significantly improve liver function and inflammatory status
in CSHB patients.

Key words: Plasmapheresis, Chronic severe hepatitis B, Inflammatory mediator