Abstract: 【Abstract】Objective To study the effect of oral nutrition supplement on nutritional status in maintenance hemodialysis (MHD) patients with protein-energy wasting (PEW). Method We investigated the prevalence of PEW by the 7-point subjective global assessment (SGA) in 192 MHD patients treated in the Blood
Purification Center of Guangzhou Red Cross Hospital in the duration from Jan. 2013 to Dec. 2014. Sixty-two MHD patients with PEW were randomly divided into control group (n=31) or oral nutrition supplement group (ONS, n=31). Changes of SGA score and nutritional status markers after intervention were compared between the two groups. Result The prevalence of PEW was 39.1% (75/192) in our center. After intervention in ONS group, serum albumin (37.19±1.54 vs. 35.18±5.11 g/L), prealbumin (305.74±43.20 vs. 275.68±65.23 mg/ L), and transferrin (1.43±0.25 vs. 1.28±0.25 g/L) increased significantly (P＜0.05) as compared with those in control group. SGA score, body weight, body mass index, upper arm circumference, and arm muscle circumference increased and C reactive protein level decreased in ONS group but without statistical significance (P＞ 0.05). Triceps skinfold thickness, total serum triglyceride and cholesterol levels were indifferent between the two groups (P＞0.05). Conclusion The prevalence of PEW was higher in MHD patients. Oral nutrition supplement can improve the nutritional status in MHD patients with PEW.

Key words: Protein- energy wasting, Hemodialysis, Subjective global assessment, Nutritional status, Oral nutrition supplement