Abstract: Objective To investigate the prognosis of patients with bee stings induced multiple organ failure (MOF) and treated with double plasma molecular absorption system (DPMAs). Methods A total of 58 cases of patients with bee stings injury and MOF were retrospectively analyzed. They were treated with blood purification and divided into three groups: DPMAs and continuous veno- venous hemofiltration (CVVH) (DPMAs-CVVH) group (n=20), hemoperfusion and CVVH (HP-CVVH) group (n=21), and plasma exchange and CVVH (PE-CVVH) group (n=17). Before treatment and after treatment for 3 days, serum myoglobin, creatinekinase, AST, total bilirubin, creatinine and procalcitonin were determined, and APACH II score and clinical conditions were evaluated. Results APACH II score and serum myoglobin, creatinekinase, AST, total bilirubin, creatinine and procalcitonin reduced significantly after the treatment in the three groups (P＜0.05). After the treatment for 3 days, myoglobin, creatinekinase, AST, total bilirubin, creatinine, procalcitonin and APACH II score decreased more in DPMAs-CVVH group than in HP-CVVH and PE-CVVH groups (P＜0.05). Additionally, clinical symptoms and patients’prognosis also improved more in DPMAs-CVVH
group than in HP-CVVH and PE-CVVH groups (P＜0.05). Conclusions DPMAs can effectively prevent organ dysfunction and improve clinical symptoms and prognosis through clearance of the toxicants. Therefore, DPMAs-CVVH is an important measure in the comprehensive treatments for MOF patients due to bee
stings.

Key words: Double plasma absorption system, Bee stings injury, Multiple organ failure