Abstract: Objective To explore the clinical effect of heterozygous blood purification on intradialytic blood pressure variability. Method Forty maintenance hemodialysis (MHD) patients with stable disease status were recruited in Hemodialysis Center of the 150th PLA Hospital. Patients were treated with routine hemodialysis
for 8 weeks followed by heterozygous blood purification for 8 weeks. Blood pressure at the first hemodialysis session of every week was recorded. The mean and standard deviation of systolic and diastolic pressure were calculated. Coefficient of variation was used to express blood pressure variation (BPV). BPV
under different treatment stages were calculated and compared. Result A total of 40 patients were enrolled. In routine hemodialysis stage, intradialytic systolic BPV was 6.45±1.78, and intradialytic diastolic BPV was 4.85±2.12; in heterozygous blood purification stage, intradialytic systolic BPV was 2.97±0.82 (P＜0.05), and intradialytic diastolic BPV was 1.67±0.43 (P＜0.05). The mean systolic and diastolic blood pressure changed insignificantly between the two treatment stages (P>0.05). Conclusion After heterozygous blood purification, intradialytic systolic BPV and diastolic BPV reduced significantly. This blood purification method needs to be further studied.

Key words: Heterozygous blood purification, Maintenance hemodialysis, Blood pressure variability