Abstract: Objective To investigate the change of pathogens, drug sensitivity and risk factors of central venous catheter-related infection in hemodialysis patients in order to improve the prevention of catheter-related infection. Methods The main pathogens for catheter- related infection were Gram- positive bacteria (66.7% ) including Staphylococcus aureus (19.6% ), Staphylococcus epidermidis (15.7% ), S.haemolyticus (11.8%) and Enterococcus faecalis (9.8%). Drug sensitivity test showed that these pathogens developed the resistance to multiple drugs including penicillin, amoxicillin, clindamycin and cefazolin with a resistance rate
of >79.3%, and were relatively sensitive to vancomycin and linezolid (resistance rate of 0～20.7%). Results showed that albumin level (χ2=5.985, P=0.045), antibiotics before catheterization (χ2=8.535, P=0.017), intubation times (χ2=11.074, P=0.008), catheter indwelling time (χ2=11.861, P=0.004) and underlying disease (χ2=11.264, P=0.007) were significant different between infection group and non-infection group (P＜0.05). Logistic regression showed that albumin level ＜35g/L (OR 1.732, 95% CI 1.084～3.123, P=0.018), intubation times ≥3 (OR 2.011, 95% CI 1.084～3.123, P=0.011), catheter indwelling time ≥2 weeks (OR 1.873, 95% CI 1.108～2.921, P=0.010) and underlying disease (OR 1.793, 95% CI 1.075～2.863, P=0.013) were the independent risk factors for catheter-related infection in patients undergoing blood purification. Results The incidence of catheter-related infection is affected by many factors. The main pathogens for catheter-related infection are Gram-positive bacteria and have the resistance to multiple drugs. In addition to the judicious use of antibiotics and prevention measures, the information about the distribution of pathogens, drug sensitivity test and related risk factors is also useful for the prevention and treatment of catheter-related infection. Conclusions The incidence of catheter-related infection is affected by many factors. The main pathogens for catheterrelated infection are Gram-positive bacteria and have a general drug resistance, based on distribution of pathogens, drug sensitivity test results and related risk factors, which should be taken effective measures to reduce the morbidity of catheter-related infection.

Key words: Hemodialysis, venous catheter, infection, risk factor, drug resistance