Abstract: Objective To investigate the incidence and control of chronic kidney disease- mineral and bone disorder (CKD-MBD) in maintenance hemodialysis (MHD) patients. Method A total of 126 MHD patients in our dialysis center were recruited. Their serum calcium (Ca), phosphorus (P) and intact parathyroid hormone (iPTH) were collected to analyze the compliance status with the required levels and to compare with the average levels of the patients in 70 hemodialysis centers in Shanghai in 2014. Calcification of abdominal aorta was evaluated by lateral plain film, and bone mineral density was measured by ultrasonic examination of the calcaneus. Results In the 126 MHD patients, 116 patients (92%) met the diagnosis criteria of CKDMBD. In the 126 MHD patients, the average levels of serum P, Ca and iPTH were 2.3±3.71 mmol/L, 2.23± 0.33 mmol/L, and 401±421 pg/ml respectively. Serum P, Ca and iPTH compliant with the required levels were 41.85%, 35.71% and 58.73%, respectively, of the patients, lower than the average levels of serum Ca and P and higher than the average level of serum iPTH in the patients in 70 hemodialysis centers in Shanghai in 2014 (35.71% vs. 48.86%, χ2=4.188, P=0.042 for serum Ca; 41.85% vs. 61.36%, χ2=21.094, P＜0.001 for serum P; 58.73% vs. 44.91%, χ2= 9.581, P＜0.001 for serum iPTH). The prevalence of abdominal aorta calcification was 74.6%, and the prevalence of CKD-MBD with low bone mineral density was 72.22%. Conclusions CKD-MBD was prevalent in MHD patients. CKD-MBD was frequently associated with low bone density, vascular calcification, and lower compliance with the required serum Ca, P and iPTH levels. Nephrologists should pay more attention to these abnormalities in MHD patients.

Key words: Chronic kidney disease-mineral and bone disorder, CKD-MBD with low bone mineral density, Vascular calcification, Calcium and phosphorus metabolism abnormality