Abstract: Objective To investigate whether diabetes mellitus affects the maturation of autologous arteriovenous fistula (AVF) after the operation for 3 months in patients with end stage renal disease (ESRD). Methods We selected patients with ESRD in the Nephrology Department of Beijing Haidian Hospital, divided them into diabetes group and non-diabetes group, collected their general information, primary disease and vascular calcification to decide the operation plan after comprehensive evaluation, and record the corresponding parameters for vessel anastomosis before AVF operation. After the operation for 3 months, fistulas were examined by ultrasound, and the related parameters were recorded. The maturation of AVF was determined by physical and ultrasound examinations. Results This study included 118 patients. The maturation rate was significantly lower in diabetes group than in non-diabetes group (72.0% vs. 95.6%, c2= 13.001, P=0.000). The prevalence of vascular calcification was significantly higher in diabetes group than in non-diabetes group (c2= 5.002, P=0.025).Univariate logistic regression analysis showed that diabetes (OR 8.426, 95% CI 2.270～ 31.283, P=0.001) and radial artery diameter <1.5mm (OR 6.257, 95% CI 2.020～19.381, P=0.001) affected the maturation of AVF (P<0.05). Binary logistic regression analysis showed diabetes (OR 9.086, 95% CI 2.302～35.866, P=0.002) and radial artery diameter <1.5mm (OR 6.789, 95% CI 2.022, P=0.002) were the independent risk factors for delayed maturation of AVF. Conclusions The prevalence of vascular calcification and delayed maturation of AVF are relatively high in patients with diabetes. Diabetes and radial artery diameter<1.5mm are the independent risk factors for delayed maturation of AVF.

Key words: Arteriovenous fistula, Diabetes, Hemodialysis