Chinese Journal of Blood Purification ›› 2016, Vol. 15 ›› Issue (12): 691-693.doi: 10.3969/j.issn.1671-4091.2016.12.010

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The relationship between transforming growth factor-β1 and intimal hyperplasia in autologous arteriovenous fistula

  

  • Received:2016-05-16 Revised:2016-09-27 Online:2016-12-12 Published:2016-12-05

Abstract: Objective To investigate the relationship between TGF- β1 and intimal hyperplasia in the dysfunction of autologous arteriovenous fistula (AVF). Methods We collected clinical data of 21 uremia patients. The hyperplasia group included 11 cases with AVF failure, and the control group included 10 cases before AVF surgery. For patients in hyperplasia group, a segment of non-functional hyperplastic vein as a sample and a piece of branch vein (not hyperplasia by naked eyes) as a self-control were taken during AVF neoplasty. For patients in control group, we took a segment of vein as controls during AVF surgery. Immunohistochemistry was used to observe intravascular TGF-β1 expression level in the vein samples. Results TGF-β1 mainly located in cytoplasm, and expressed highly in hyperplasia veins and weakly in veins of self-controls and control group. The expression of TGF-β1 in hyperplasia veins was higher than that in veins of self-controls and control group (P<0.01), but without significant difference between veins of self-controls and control group (P>0.05). Conclusion The high expression of TGF-β1 in hyperplasia veins may correlate with the intimal hyperplasia in AVF. Inhibition of TGF-β1 in local veins may beome a measure for the treatment of AVF dysfunction.

Key words: Autogenous arteriovenou fistula, Intimal hyperplasia, TGF-β1, Uremia