Abstract: Objective To investigate the removal of serum β₂-microglobulin during on-line hemodiafiltration using a domestic hemofilter. Methods In this single center, self-control, open-label clinical study, 30stable hemodialysis patients whose serum β₂-microglobulin increased to more than 10 times above the upper
normal limit were chosen to receive post- dilution online hemodiafiltration using a domestic hemofilter(Lengthen, membrane area 1.4m²) or an imported hemofilter (Toray, membrane area 1.6m²). Reduction ratio (RR) of β₂-microglobulin was assessed. Results The RR of serum ß₂- microglobulin was similar after online hemodiafiltration using a Lengthen (71.729%± 7.393%) hemofilter and a Toray hemofiter (74.707%±7.889%, t=1.508, P=0.137). Conclusion There was a good removal effectiveness of ß₂-microglobulin when the domestic hemofilter was used in post-dilution online hemodiafiltration.

Key words: Hemodiafiltration, β₂-microglobulin, Domestic hemofilter