Abstract: Objective To explore the risk factors for catheter- related bloodstream infection (CRBSI) in end-stage renal disease patients in order to provide references and suggestions for the prevention of CRBSI. Methods We recruited age, gender, type of central vein catheterization (CVC), serum albumin, serum total protein, hemoglobin, diabetes, co-infection of 343 patients (50 cases with CRBSI and 293 cases without CRBSI) using CVC for hemodialysis access during Jan. 1, 2013 to Dec. 31, 2014. Clinical data were analyzed by SPSS 21.0, and P＜0.05 was defined as statistical significance. Results After analyses of clinical data, we found that femoral vein catheterization was more susceptible to CRBSI than internal jugular vein catheterization (χ²=19.107, P＜0.001), temporary catheterization was more susceptible to CRBSI than long-term catheterization (χ²=8.009, P=0.005), and patients with co-infection were more susceptible to CRBSI than those without co-infection (χ²=4.248, P=0.039). Age was younger in the CRBSI group than in the non-CRBSI group (t=-2.123, P=0.034). Serum albumin was lower in the CRBSI group than in the non-CRBSI group (t=-2.177, P=0.030). There were no differences in gender (χ²=1.662, P=0.197), diabetes (χ²=0.004, P=0.948), serum total protein (t=- 1.530, P=0.127), and hemoglobin (t=- 0.846, P=0.388) between the two groups. Conclusions CRBSI is a common complication in hemodialysis patients. The prevalence of CRBSI may relate to the type of CVC, serum albumin and co-infection in hemodialysis patients

Key words: hemodialysis, catheter-related bloodstream infection（CRBSI）, risk factor