Abstract: Objective To explore clinical features and influence factors on the prognosis in type 1 cardiorenal syndrome (CRS) patients treated with continuous renal replacement therapy (CRRT). Methods Fiftythree patients admitted to Beijing Anzhen Hospital due to type I CRS and treated with CRRT from January 2008 to March 2016 were enrolled in this retrospective study. They were divided into two groups according to survival or death. Patients in the survival group were further divided into two subgroups according to their prognosis, renal replacement therapy (RRT) independent subgroup and RRT dependent subgroup. Baseline features, diagnosis, complications, combined drug therapy, cardiac function and renal function before CRRT and at the beginning of CRRT were compared respectively between the two subgroups. Results The average age of the 53 patients (36 males and 17 females) was 65.8 years old. Thirty of them were survival with the mortality rate of 43.4%. Twenty-one of the 30 survival patients improved without the need of dialysis anymore, and 9 cases must rely on maintenance dialysis. Compared with the patients in the survival group, patients in the death group had lower urine volume before CRRT (t=-2.336, P=0.023), later CRRT beginning time (t=2.187, P=0.038), higher prevalence of intradialytic hypotension (χ2=16.246, P＜0.001), higher proportion of using vasoactive drugs (χ2=12.106, P=0.001), and less decrease of serum BNP after CRRT (t=15.931, P＜0.001). In the RRT independent subgroup, serum creatinine at baseline (t=- 4.796, P=0.001) and before CRRT (t=-2.502, P=0.018) were significantly lower than those in the RRT dependent subgroup. Conclusion The mortality was relatively high in type I CRS treated with CRRT. The risk factors for death were lower urine volume, late beginning of CRRT, intradialytic hypotension, and persistent higher BNP level after CRRT. The risk factor for RRT dependence was the higher baseline serum creatinine before CRRT.

Key words: cardiorenal syndrome, Continuous renal replacement therapy, prognosis, influence factor