Abstract: Hepatitis B virus infection is a global public problem. Because of the lack of typical clinical manifestation, occult hepatitis B infection is often unaware by the majority of infected people, leading to spread of the infection. Serological markers of HBV and quantification of HBV DNA can virtually reflect status of hepatitis B virus infection. This article aims to discuss HBsAg and anti-HBs antibody, HBeAg and anti- HBe antibody, anti-HBc antibody, HBV DNA, and newly discovered biological markers for HBV replication in vivo.

Key words: Hepatitis B infection, HBsAg and anti-HBs antibody, HBeAg and anti-HBe antibody, Anti-HBc antibody, HBV DNA