Abstract: On- line hemodiafiltration（OL-HDF）is an important method of renal replacement therapy, which combines hemodialysis and hemofiltration characteristics. The ultra-net replacement fluid is generated on line and it greatly improved the ability to remove toxins in the body. Meanwhile, it is conducive to maintaining the stability of hemodynamics during dialysis and has a protective effect on the cardiovascular system of dialysis patients. In this review, we summarize the clinical benefit and research progress of OL-HDF.

Key words: on-line HDF, hemodialysis, toxin removal, cardiovascular protection, survival rate