Abstract: Metabolic acidosis is a common complication in chronic kidney disease patients. It is funda mental for the treatment of multiple systemic complications of chronic kidney disease to correction of metabolic acidosis. For the patients undergoing hemodialysis, the acid-base balance depends on many factors, including body net acid generation, the total amount of the alkali obtained from the dialysate,duration of the interdialytic period,and residual renal function.This paper will mainly discuss the effect of dialysate bicarbonate concentration on prognosis in dialysis patients.

Key words: Dialysate bicarbonate concentration, Metabolic acidosis , Chronic kidney disease, Hemo ?dialysis