Abstract: 【Abstract】An elderly male was diagnosed as monoclonal immunoglobulin (IgM, kappa), type I cryoglobulinemia and renal failure due to cryoglobulinemia. After renal biopsy, his hemoglobin decreased progressively, and renal ultrasound showed a hematoma of 108×76mm around right kidney. After DSA examination, he was immediately treated with continuous veno-venous hemodialysis (CVVHD). During the treatment, pre-filtration pressure rose to 450mmHg, and premature clotting in filter due to cold agglutination of cryoglobulin was identified. The clotting disappeared after external heating of the circuit before the filter. We report this case her to be aware of the similar patients clinically and to treat this situation appropriately in the future.

Key words: Cryoglobulinemia, Continuous veno- venous hemodialysis therapy, Premature filter clotting, Nursing